all my numbers look normal except my CCP Antibody IgG is > 500 (where they same normal range is < 16). These values do not apply to results that are converted to other units of measure. Many studies have shown that CCP antibodies provide a more accurate diagnosis of rheumatoid arthritis compared with RF testing. Another test which is ordered when rheumatoid arthritis is suspected is the anticyclic citrullinated peptide (anti-CCP). ; 2018 Oct 27 [cited 2020 Feb 12]; [about 3 screens]. Remember to talk to your doctor before starting any new supplement or making significant changes to your diet. In seropositive RA, blood tests show unusually high levels of antibodies called anti-cyclic citrullinated peptides (anti-CCPs). [4][5] Subsequent studies demonstrated that autoantibodies from RA patients react with a series of different citrullinated antigens, including fibrinogen, deiminated Epstein-Barr Virus Nuclear Antigen 1 and vimentin,[6][7][8] which is a member of the intermediate filament family of proteins. Washington D.C.: American Association for Clinical Chemistry; c20012020. Both tests are used to test disease activity; when they are high,this suggests that the disease is very active (assuming no other causes for high results, such as infection, are present). The test is also known as an anti-citrulline antibody, cyclic citrullinated peptide antibody (CCPA), anti-cyclic citrullinated peptide antibody, and anti-CCP. The CBC tests help to inform the healthcare team about side effects of treatment and any secondary consequences of RA, such as anemia. A study has shown that the anti-CCP test can assist in the diagnosis of rheumatoid arthritis with a positive likelihood ratio of around 14 and a specificity of around 96 percent. Prior to the discovery and testing of anti-CCP, most doctors used rheumatoid factor (RF) another antibody as a test to help reach a rheumatoid arthritis diagnosis. my arthritis pain is VERY low. 2. These are done to check for other potential health issues, especially anemia and signs of inflammation, that are common with individuals who have rheumatoid arthritis. Vitamin D may help lower anti-CCP antibodies by suppressing overactive immune cells that attack the bodys own proteins and tissues [17]. But RF factors can be found in people with other autoimmune diseases and even in some healthy people. What do high CCP IgG blood test results indicate? PMID 29628436; PMCID: PMC6014894. However, data from all around the world vary substantially. Often the anti-CCP antibody will be found in patients' blood anywhere from 5 to 10 years before they ever exhibit symptoms of rheumatoid arthritis. Pak J Med Sci. Presence of the anticyclic citrullinated peptide (CCP) antibody is considered a hallmark of rheumatoid arthritis, and may be found in patients with other rheumatic diseases, including psoriatic arthritis (PsA). Rheumatoid arthritis can be difficult to diagnose, especially in its early stages. A blood sample is drawn from the patient and analyzed in a lab. This includes a complete blood count, synovial fluid testing, and ANA blood tests. Available from: Cleveland Clinic [Internet]. The presence of autoantibodies against citrullinated proteins in rheumatoid arthritis patients was first described in the mid-1970s when the biochemical basis of antibody reactivity against keratin and filaggrin was investigated. 2013 May-Jun [cited 2020 Feb 12]; 29(3):773-77. CCP testing was performed mainly to evaluate patients with joint pain. Available from: Lab Tests Online [Internet]. Anti-CCP or Anti-Cyclic Citrullinated Peptide is an autoantibody also known as ACPAs or anti-citrullinated protein antibodies. If a patient tests positive for anti-CCP, it doesnt immediately lead to a rheumatoid arthritis diagnosis. These patients are considered to have "seronegative rheumatoid . Some individuals may experienced the development of nodules near the elbow. in 2008 from UT Health San Antonio, Surgeon at TRACC Dallas. This test is also done to prognosticate rheumatoid arthritis, as well as differentiating it from other kinds of arthritis. Perhaps you need to be on other medicines for this condition. Maksymowych WP, Naides SJ, Bykerk V, et al. There is very little risk to having a blood test. Among seropositive patients, 22% had only anti-CCP antibodies. Rheumatoid Arthritis; [updated 2018 Aug 28; cited 2020 Feb 12]; [about 3 screens]. You may need this test if you have symptoms of rheumatoid arthritis. We do not aim to diagnose, treat, cure or prevent any illness or disease. The RA associated citrullinome has been reported to include targets from synovial fluid and tissue that range from proteases, receptors, and carrier proteins. The meaning of these results may depend on the results of a rheumatoid factor (RF) test as well as a physical exam. A CCP antibody test requires a blood sample. In addition to laboratory criteria, a patient must also exhibit clear clinical symptoms that are consistent with rheumatoid arthritis. when I get a cold it get a small flare up but other than that, I am able to play racquetball for a least 2 hours 6 days a week and can do regular activities (job, wife, kids, evening school, etc..). Blood sample Order now PATIENTS HEALTHCARE PROVIDERS Anti-CCP Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. When RF serostatus (yes/no) was included in the model instead of anti-CCP serostatus, no association with osteopenia in femoral neck/ward was found (data not shown). Hello: my CCP has climbed up in the past year from ~25 to ~77 to ~147. Anti-CCPs are antibodies also produced by the immune system. Autoantibodies can cause disease by attacking the body's healthy cells by mistake. Once a patient develops a positive anti-CCP, it will usually remain positive, despite remission. 7. Also, the stimulating effects of caffeine help to fight physical and mental fatigue that is common with rheumatoid arthritis. They are almost never found in people who don't have the disease. Antibodies and autoantibodies are proteins made by the immune system. When you test positive for rheumatoid factor and/or another autoantibody called anti-cyclic citrullinated protein (anti-CCP) you are considered to have "seropositive rheumatoid arthritis.". These antibodies are detected in the laboratory using artificial cyclic citrulline peptides (anti-CCP Ab).This assay is far more sensitive and specific than rheumatoid factor . Anti-CCP: Anti-Cyclic Citrullinated Peptide Antibody Also known as Anti-Citrullinated Protein Antibody (ACPA) Useful in diagnosis and prognosis of rheumatoid arthritis (RA) Newest anti-CCP assay yields a specificity of 98%, the sensitivity of 80% for RA Present in 70% of patients with established RA What is Anti-CCP? It is hypothesized that the lung inflammation caused by smoking could possibly lead to developing the anti-CCP antibodies in patients who possess this shared epitope. There have however been reported significant falls in patients clinically responding to infliximab and to rituximab; anti-CCP has been . These include: You may also need this test if other tests couldn't confirm or rule out a diagnosis of rheumatoid arthritis. Antibodies protect you from disease by fighting foreign substances like viruses and bacteria. Combination of anti-CCP with other serological markers like rheumatoid factor, 14-3-3 (YWHAH) not only enhances the diagnostic capture rate but together with acute phase reactants either in early disease or at the time of diagnosis may be useful in predicting future outcomes. Rheumatoid arthritis is a clinical diagnosis. The cost to maintain this website grows each week. This is usually referred to as seronegative rheumatoid arthritis. Despite these rare cases, a positive anti-CCP test is considered highly specific to rheumatoid arthritis (meaning a negative test does not rule out the disease, but a positive result rules it in). Vitamin D deficiency is linked to both rheumatoid arthritis and higher anti-CCP antibodies. Omega-3s reduced inflammation in people with high anti-CCP, but more studies are needed. Some researchers feel that there is a strong connection between smoking and rheumatoid arthritis patients who have this shared epitope. We keep the number of high qualtiy advertisers very low. Rheumatoid factors are another type of autoantibody. In 2010, ACPA testing has become substantial part of The 2010 ACR-EULAR classification criteria for rheumatoid arthritis. Anti-CCP is an autoantibody. Health Encyclopedia: CCP; [cited 2020 Feb 12]; [about 2 screens]. Quitting smoking may help reduce inflammation in people with rheumatoid arthritis and high anti-CCP levels. Rochester (NY): University of Rochester Medical Center; c2020. Frequent flare-ups and reduced remission periods can be expected in this group of patients. Pain so far is occasional but we'll see how it goes. This means that the patient's immune system produces antibodies that identify the patient's cells as foreign material and as a result, attack its own normal cells. This test, however, can be influenced by factors such as obesity and infection and is not specific to RA. Rheumatoid factor (RF) was the first autoantibody to be discovered in people with RA. 2018 Jun 21;25(6):691704.e6. The normal level of anti-CCP is less than 20 u/ml. Anti-CCP positive testing is also used to help doctors deliver a prognosis because many anti-CCP positive patients experience severe rheumatoid arthritis symptoms. Once the diagnosis of RA has been made and confirmed, these tests are not repeated. A CCP antibody test is used to help diagnose rheumatoid arthritis. 121 S. Orange Ave Treatment with infliximab has resulted to . 14-3-3: a novel biomarker platform for rheumatoid arthritis. Rheumatoid factor was positive in 39/67 (58%) with erosive disease, vs. 11/37 (30%) with non-erosive disease. Enter a Melbet promo code and get a generous bonus, An Insight into Coupons and a Secret Bonus, Organic Hacks to Tweak Audio Recording for Videos Production, Bring Back Life to Your Graphic Images- Used Best Graphic Design Software, New Google Update and Future of Interstitial Ads. Studies show that in anti-CCP positive patients, higher levels of omega-3s slowed the progression of inflammatory arthritis symptoms, but further study is needed [20, 22]. This test looks for CCP (cyclic citrullinated peptide) antibodies in the blood. It is worth noting that not all patients with low levels of anti-CCP mean that the result is positive. In certain cases, positive anti-CCP tests may also indicate the possibility of other conditions besides rheumatoid arthritis. Anti-MCV levels in the cases . 3 out of 4 people who are affected by RA fit into this specific demographic. What is Anti-CCP or ACCP test? This may also occur in the feet, knees, hip,s elbows, shoulder, or the neck. The anti-CCP Master curve material (Siemens Healthineers) with 5 preassigned levels of 0.4, 45, 90, 135, and 180 U/mL was tested in duplicate, and the linearity was evaluated by comparing against expected concentrations calculated from the linear fit and statistically best polynomial fit. Some labs report this sameresultusing a different measurement notation, that is, asless than 20EU/ml.) [6][17] Noteworthy are the findings of a recently published study that highly valuates anti-MCV test systems for diagnosing rheumatoid arthritis in anti-CCP-negative patients. About 20% of RA patients are seronegative, meaning that their RF and anti-CCP lab results both continue to come back negative. Anti-CCP antibody may be associated with a higher incidence of ILD in SSc. As a result, this test also helps doctors pursue specific and possibly more aggressive treatment options. If you continue to use this site we will assume that you are happy with it. A person who manifests signs and symptoms of inflammatory arthritis is usually prescribed to undergo an anti-CCP blood test. doi: 10.1016/j.chembiol.2018.03.002. Natural Factors That May Decrease Inflammation in Joint Disease Other diseases that can lead to increased RF levels include chronic infection, cirrhosis, or scarring of the liver, cryoglobulinemia (or abnormal proteins in the blood), dermatomyositis (an inflammatory muscle disease), inflammatory lung disease, mixed connective . Medical records were reviewed through February 2018. It typically is higher in the joints of people with Rheumatoid Arthritis ( RA) Given the high number it's possible this person has RA. 20 1.3 21 PICO table Los anticuerpos nos protegen de las enfermedades combatiendo sustancias extraas como los virus y las bacterias. A blood sample is required for a CCP antibody test. In some instances, patients with negative anti CCP test still manifest symptoms of rheumatoid arthritis. Most patients with rheumatoid arthritis have anti-cyclic citrullinated peptide (anti-CCP). C-reactive protein is a measure of clinical inflammation often used in addition to an ESR. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at support@selfdecode.com. CCP antibodies are produced by the immune system and can mistakenly attack healthy tissues. Monica Richey, MSN, ANP-BC/GNP
the titre of anti-CCP does not fall with 'standard' anti-rheumatic therapy (unlike RF). An anti-CCP result up to 20 u/mL is considered negative, according to the Hospital for Special Surgery. When a doctor tests for RF levels, they may also perform an anti-CCP test. Early detection can help patients to maintain their quality of life and prevent the severe progression of rheumatoid arthritis. The meaning of these results may depend on the results of a rheumatoid factor (RF) test as well as a physical exam. It is calculated by measuring the rate at which red blood cells sediment in a test tube in one hour. Cyclic Citrullinated Peptide Antibody; [updated 2019 Dec 24; cited 2020 Feb 12]; [about 2 screens]. Anti-cyclic citrullinated peptide (anti-CCP): the doctor will draw a blood test to run Anti-CCP. In order to reach a rheumatoid arthritis diagnosis when a patient tests positive for anti-CCPs, several other criteria must be met. If the patients hemoglobin levels indicate anemia, this will be further investigated looking for its cause. What Happens If CCP Antibody Is Positive? In a study of over 200 people, lower vitamin D levels were linked to higher anti-CCP antibody levels [17]. Higher levels of antibodies to P. gingivalis are linked to higher levels of citrulline [3]. Information is shared for educational purposes only. While a high CCP may mean a possibly aggressive disease course, it must be looked at with the amount of swelling, inflammation in the blood, and the number of joints involved. 5 Whats the normal range for an anti CCP test? The reference ranges for blood tests of anticitrullinated protein antibodies are: Anti-CCP is part of the 2010 ACR/EULAR classification criteria for Rheumatoid Arthritis. Gum disease (periodontal disease) is often caused by an infection by the bacteria P. gingivalis [3]. Signs and symptoms may include: If these are felt, then the anti-CCP blood test may be required by your doctor. SelfDecode is a personalized health report service, It also helps in prognosticating aggressive joint erosion. Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis, anti-mutated citrullinated vimentin (Anti-MCV) is another anti-citrullinated antibody reacting with mutated citrullinated vimentin. It's a newer, much more accurate test. Atlanta: Arthritis Foundation; Rheumatoid Arthritis; [cited 2020 Feb 12]; [about 3 screens]. Our goal is to not have a single piece of inaccurate information on this website. A related blood test known as anti-cyclic citrullinated peptide (anti-CCP) test is also available. How do I move my physical server to Azure? Atlanta: American College of Rheumatology; c2020. Vitamin D deficiency is linked to both a greater risk of developing rheumatoid arthritis and more severe arthritis symptoms such as pain, swelling, and inflammation in existing patients [15, 16]. OBJECTIVE To examine the association of treatment response and disease duration with changes in rheumatoid factor (RF) and anti-cyclic . This means that the patients immune system produces antibodies that identify the patients cells as foreign material and as a result, attack its own normal cells. Omega-3 fats help by reducing inflammation that can increase the citrullination of proteins leading to an immune system reaction and increased anti-CCP [20, 21]. On the other hand, the presence of erosions at baseline predicted an increase in anti-CCP levels (+1.6 U/mL/mo, P =.008). Since her cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor tests were positive, rheumatoid arthritis (RA) was diagnosed and she was started on prednisone with plans for additional disease modifying therapy. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. RASN is dedicated to providing the most up to date and trusted information. 2007. In turn, understanding how the results of blood tests used to monitor RA and its treatment can help patients better able to manage their RA. Your rheumatologist may be taking a conservative . Some labs report this same result using a different measurement notation, that is, as less than 20 EU/ml.) Conversely, elevated levels of all three do not mean a person has RA. Maksymowych WP, Marotta A. A negative anti-CCP test does not rule out RA, however, as about 20% of RA patients are seronegative for anti-CCP. Rheumatoid Factor (RF); [updated 2020 Jan 13; cited 2020 Feb 12]; [about 2 screens]. 6 Where are anti CCP antibodies found in the body? Both the CBC and the complete metabolic panel are used to monitor disease activity as well as side effects and efficacy of medication. 1 What is considered a high anti-CCP level? The mean level of anti-CCP antibodies declined by 131 U/ml during the 3 year follow up (95% CI 34 to 228 U/ml). A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. But then there are doctors who just dont want to give a definitive diagnosis for whatever reason. Anti-cyclic citrullinated peptide (anti-CCP) is an antibody present in most rheumatoid arthritis patients. How to differentiate between UTI and Pregnancy Symptoms? They are never enough alone to diagnose RA. Epub 2014 Jul 3. Compared with anti-CCP- patients, anti-CCP+ patients had a significantly higher 10-year probability of major fracture and a significantly lower BMD of the . Some researchers believe that the shared epitope is what attaches to these proteins and produces the anti-CCP antibodies. Although several studies have been published aiming to identify the prevalence of anti-CCP in patients with different rheumatic conditions2,3,4 . Citrullinated vimentin is a very promising autoantigen in RA, and a suitable tool for studying this systemic autoimmune disease. Other names: Cyclic citrullinated peptide antibody, anticitrullinated peptide antibody, citrulline antibody, anti-cyclic citrullinated peptide, anti-CCP antibody, ACPA. The result is positive if the blood sample contains anti-CCP at a specified level. [20], Given that ACPA are more specific than rheumatoid factor, they are used to distinguish various causes of arthritis. Original summary written by Lysa Petrsoric, MPH, MSW, April 20, 2015, and edited by Nancy Novick. laboratory tests, reference ranges, and understanding results, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809312, https://www.rheumatology.org/Learning-Center/Glossary/ArticleType/ArticleView/ArticleID/439, https://www.arthritis.org/diseases/rheumatoid-arthritis, https://my.clevelandclinic.org/health/diseases/4924-rheumatoid-arthritis/diagnosis-and-tests, https://familydoctor.org/condition/rheumatoid-arthritis, https://www.hss.edu/conditions_understanding-rheumatoid-arthritis-lab-tests-results.asp, https://labtestsonline.org/tests/autoantibodies, https://labtestsonline.org/tests/cyclic-citrullinated-peptide-antibody, https://labtestsonline.org/glossary/inflammation, https://labtestsonline.org/tests/rheumatoid-factor-rf, https://www.mayoclinic.org/diseases-conditions/rheumatoid-arthritis/diagnosis-treatment/drc-20353653, https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/84182, https://www.merckmanuals.com/home/bone,-joint,-and-muscle-disorders/joint-disorders/rheumatoid-arthritis-ra, https://www.nhlbi.nih.gov/health-topics/blood-tests, https://www.rheumatoidarthritis.org/ra/diagnosis/anti-ccp, https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=ccp, U.S. Department of Health and Human Services, Joint stiffness, especially in the morning. Washington D.C.: American Association for Clinical Chemistry; c20012020. These antibodies are produced by the person's immune system and identify the body's tissue cells as foreign bodies and attack them. Anti-CCP is an antibody which is present in majority of RA patients. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Dental treatment that removed P. gingivalis reduced the production of citrulline in 55 RA patients [3]. CCP antibodies target healthy tissues in the joints. The participants were categorized into two groups according to anti-CCP-positive (anti-CCP+) or anti-CCP- status and into four groups (I-IV) according to the anti-CCP level quartiles. A negative result means no CCP antibodies were found. Get more fiber in your diet with foods such as: fresh fruits and vegetables. Contact a health care provider if you have questions about your health. However anti-CCP is not associated with extraarticular features (unlike RF) variation of levels with treatment of RA. "Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis", "2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative", "Anti-keratin antibodies in rheumatoid arthritis", "The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies", "Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin", "Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anti-citrullinated protein antibodies in rheumatoid arthritis", "Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis", "Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis", "The devil in the details: the emerging role of anticitrulline autoimmunity in rheumatoid arthritis", "Clinical evaluation of anti-mutated citrullinated vimentin by ELISA in rheumatoid arthritis", "Diagnostic value of the anti-Sa antibody compared with the anti-cyclic citrullinated peptide antibody in rheumatoid arthritis", "Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in rheumatoid arthritis patients and relatives from Brazil", "Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review", "Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy", chronolab.com > Autoantibodies associated with rheumatic diseases > Reference ranges, https://en.wikipedia.org/w/index.php?title=Anticitrullinated_protein_antibody&oldid=1131353728, This page was last edited on 3 January 2023, at 19:50. Result LOINC Value. The Arthritis Foundation states that foods high in fiber can reduce the amount of C-reactive protein (CRP) in your blood. Biospecimen Retention: Samples Without DNA If anything fails to meet your standards in any way please contact us so that we may consider removing it from our recommendations. Anti-CCP Abs are considered of special interest in the diagnosis of seronegative RA. If the sample finds the presence of anti-CCP at a certain level, the result is positive. The basis for determining the positive or negative anti-CCP result is 20 u/mL. Available from: University of Rochester Medical Center [Internet]. Anti-CCPs are antibodies the immune system also produces. Hello. Q J Med 100, 193-201. But, this may be dependent on many factors and may be different on each person. If both . Clin Exp Rheumatol. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. The effects are specific of the immune cell targeted, promoting overexpression of thrombotic, inflammatory, and pro-oxidative markers in monocytes; pro-oxidative status in neutrophils; and proinflammatory profile in lymphocytes. Normal values (negative result) are <20 EU/mL. (At Hospital for Special Surgery, anti-CCP is reported in Units. Anti-nuclear antibody (ANA) Anti-cyclic citrullinated peptide (anti-CCP) antibodies C-reactive protein (CRP) Erythrocyte sedimentation rate (ESR, or sed rate) The amount of rheumatoid factor in your blood may also help your doctor choose the treatment approach that will work best for your situation. ACPAs have proved to be powerful biomarkers that allow the diagnosis of rheumatoid arthritis (RA) to be made at a very early stage. Autoantibodies; [updated 2019 Nov 13; cited 2020 Feb 12]; [about 3 screens]. Dr. Charles Talakkottur answered Internal Medicine 63 years experience Yes but less likely: Anti ccp is fairly specific for ra. My anti ccp was 281 , RF 40 and esr, Crp all normal back in July 2016 and in march this year it's now 97.5., Crp and esr still normal , didn't do rf for some reason. He is the author of numerous health-related books and contributor to several medicine, health and wellbeing websites. For this reason, only a medical provider will be able to interpret individualized test results and compare them with symptoms to determine a diagnosis. This process may well be the cause of the inflammatory process since citrullinated proteins and the enzymes responsible for producing them are found in inmflamed synovium. Anti-CCPs can also exist in a patient for years before they ever develop clinical rheumatoid arthritis symptoms. Anticyclic citrullinated peptide (anti-CCP) antibody levels are characteristically elevated in rheumatoid arthritis, although they can be elevated in other rheumatologic conditions associated with inflammatory arthritis, such as systemic lupus erythematosus. RF above 20 IU/ml is not considered enough to diagnose RA, as there other reasons the RF level may be elevated. my arthritis pain is VERY low. They are present in the majority of patients with rheumatoid arthritis. Cleveland (OH): Cleveland Clinic; c2020. Natural Factors That May Decrease Inflammation in Joint Disease, Joe Cohen flipped the script on conventional and alternative medicine and it worked. High levels of CCP antibodies have also been discovered in connective tissue diseases, autoimmune disorders, and particularly with some forms of lupus. is anyone else doing regimine like this? The levels of antibodies will fluctuate over time if a positive test result is received. In case studies, higher omega-3 fatty acid levels are associated with a lower risk of anti-CCP antibody production [18, 19]. Learn more about the HSS Early RA Support and Education Program, a free support and education group, developed specially for people recently diagnosed with RA and early RA. Orlando (FL): Rheumatoid Arthritis Support Network; RA and Anti-CCP: What is the Purpose of an Anti-CCP Test? High levels of CCP antibodies have also been discovered in connective tissue diseases, autoimmune disorders, and particularly with some forms of lupus. The normal measurement is less than 1.0 in many labs. All rights reserved. They are present early in the disease process and have not been found consistently in any other autoimmune disease syndrome.