We respect your privacy FMC Privacy Policy. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. ). No. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Millipore. ( The aqueous solution to barrier membrane coating. EINECS #: 232-674-9 1.7. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. 2021 Annual Report. There may be more fiber in your food than you realized. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Powder becomes slippery when wet. 2 0 obj
Microcrystalline Cellulose / Avicel PH-102. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR
e,cqO! Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. } !1AQa"q2#BR$3br Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . . However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? . Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. No. /MediaBox [0 0 612 792]
Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. undefined. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Watch Now. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& }o]X4]. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. 4 0 obj
The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. CAS #: 9004-34-6 1.6. The figure below illustrates the structural organisation of cellulose within plants. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. pH 6.0 to 8.0 . The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. INCI. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. ( !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b 4. POLYOX resins are nonionic polyethylene oxide solubility polymers. CAS #: 9004-34-6 . : 160182. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. Avicel PH-200 microcrystalline cellulose NF, Ph. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Chemical Formula: (C6H10O5)n 1.4. Protect them from sunshine or rain. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >>
Product Name: Microcrystalline Cellulose E460 1.2. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. It is a white, free-flowing powder. In 1964 FMC, Corporation . ( )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Well-recognized product that can do it all. We know that our customers need to provide reliable and consistent products to their patients. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Avicel Microcrystalline Cellulose Physical Properties. 5 0 obj
Material safety data sheet - FMC Corporation. 51395-75-6 Avicel RC 591. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. MATERIAL SAFETY DATA SHEET. BIOACCUMULATIVE POTENTIAL 4 0 obj
We can send by Fedex, by ship or by plane according to international rules. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. gac74
[#B6`Wnw7 Trademarks: Avicel PH-102. (Microcrystalline Cellulose Market Pr. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). PDF (2.77 mb) 2021 FMC Sustainability Report. 0.25 - 0.37. Earth Supplied Products LLC. MATERIAL SAFETY DATA SHEET. Are you sure you want to delete your template? In large quantities it provides dietary bulk and may lead to a laxative effect. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.)
xv}O2' H~KEe9>G/,:9\i AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. G2W4de=u183KGH{ vQ#4:1\wc <>
Buy Chemicals. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Avicel PH-101. SCMm_>x^O9l (n. Microcrystalline Cellulose Side Effects. Go to Investor Relations. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>>
Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. };khd5x=fr 9,LL!z CAS #: 9004-34-6 microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. X\o^ The cellulose molecule is formed through repeated condensation of cellobiose units. SUBSTANCE IDENTIFICATION 1.1. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. "R}~Q:~pgg'"l/O:OV~
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The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. By producing Avicel . (1962). %
These grades have particle sizes ranging from <30 to approximately 200. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). /Parent 3 0 R
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%QL((((((((((((((((((((((((((((((((((((((((P3NhC 1.3. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. stream
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. cas:9000-11-7 msds Carboxymethyl cellulose. 130. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. /Type/Page
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Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . The short-term limit for total inhalable dust is 20 mg/m3. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . : 51395-75-6 Date Approved: 01/31/2008 Revision No. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. PDF (28.38 mb) 2022 Corporate Fact Sheet. : 5. Apply today! Heavy metals, % NMT 0.001 Cellulose microcrystalline for column chromatography. CAS 9004-34-6. <>
gwf;J(e0o|1p{R~P^);ao!%{0KD7. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. /Resources 2 0 R
FMC, JRS and Mingtai were estimated to hold for . Microcrystalline Cellulose E460 MSDS 1. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Learn about FMC's industry leading goal of net-zero emissions by 2035. An agricultural sciences company. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. q86@on$^X_HuH;3` Avicel Microcrystalline Cellulose: Chemical Identifiers. Looking for FMC'searnings news? The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. No. Product and Company Identification . FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. endobj
High performance lubricant that brings more to the tablet. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. l~5C
Have an order or account question? It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. Wu, K. Zuurman, H.W. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM
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It is, however, a good source of fibre. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Synonyms: Cellulose, Cellulose powder, Cotton linters. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, . A family of polysaccharide products that allow distinctive drug delivery solutions. Quick Links. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Remove HMo@9, U Q!R/1*;` Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. <>
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It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Revision No. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. <
gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Superior Performance: Provides excellent water uptake and rapid swelling . w !1AQaq"2B #3Rbr Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. %
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ChemicalBook. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. It is also used in plaque assays for counting. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. LOT #: Available upon request. Report Category. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Microcrystalline cellulose is a commonly used excipient in the . q9;v80 %PDF-1.4
1.3. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. : 160182 Date Approved: 05/25/2010 Revision No. >>
Eur., JPE . F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Product Name Cellulose microcrystalline. PharmaCentral 2021 . Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. Fiber supplements can lessen the absorption of some . Request media, explore upcoming events and read our latest updates. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Explore how you can develop your career and bring your creative ideas to life at IFF. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Manufactured by: China . Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. P}MFbN#[>r(y /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.)
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kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM PDF (4.11 mb) Footer menu 1. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. 2008-2023 ChemPoint. In extrusion-spheronisation, it is the excipient of choice. Revision No. . Gloves, eye protection and a dust mask should be used. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Van Veen, G.K. Bolhuis, Y.S. %
To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). AVICEL RC 581. SDS. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. <<
This Microcrystalline Cellulose . Test Data Available. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Microcrystalline Cellulose (MCC) Manufacturing Industry. Validity Area. No. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures.