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No studies met the inclusion criteria for this review. Aetna considers genotyping of BLVRA, SLCO1B1 and UGT1A1 experimental and investigational for assessing risk of neonatal hyperbilirubinemia because the clinical value of this approach has not been established. (For the definition of critically ill or injured see the Critical Care Services subsection of CPT before codes 99291-99292.) 6A650ZZ - Phototherapy, Circulatory, Single Version 2023 Billable Code ICD-10-PCS Details 6A650ZZ is a billable procedure code used to specify the performance of phototherapy, circulatory, single. Indirect evidence from 3 descriptive uncontrolled studies suggested favorable associations between initiation of screening and decrease in hyperbilirubinemia rates, and rates of treatment or re-admissions for hyperbilirubinemia compared with the baseline of no screening. In: Nelson Textbook of Pediatrics. They used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL 2018, Issue 5), Medline via PubMed (1966 to June 14, 2018), Embase (1980 to June 14, 2018), and CINAHL (1982 to June 14, 2018). The ball at the proximal end of the femur is supposed to fit snuggly into the acetabulum (the cup-shaped depression in the pelvis). Some infants may require intensive care services but do not meet the CPT definition of critically ill or injured required for reporting of critical care services. 1994;61(5):424-428. .headerBar { Travan et al (2014) examined if UGT1A1 promoter polymorphisms associated with Gilbert Syndrome (GS) occur with a greater frequency in neonates with severe hyperbilirubinemia. A total of 10 publications (11 studies) were eligible. In most of the trials, Field massage was given; 6 out of 8 trials reported reduction in bilirubin levels in term neonates. Okwundu CI, Okoromah CA, Shah PS. Synthesis Without Meta-analysis (SWIM) guidelines were used for reporting methods and results of synthesis without meta-analysis. Can Nurse. If the condition involves a diagnostic study, however, it is coded. Montreal, QC: CETS; October 2000. No association was found between the UGT1A1*28 allele and extreme hyperbilirubinemia. Although the duration of phototherapy in the zinc group was significantly shorter compared to the placebo group (n = 286; MD -12.80, 95 % CI: -16.93 to -8.67), the incidence of need for phototherapy was comparable across both the groups (n = 286; RR 1.20; 95 % CI: 0.66 to 2.18). Semin Fetal Neonatal Med. Li Y, Wu T, Chen L, Zhu Y. .newText { 2001;108(1):175-177. Secondary outcomes included incidence of jaundice, TSB level at 24, 48, 72, 96hours, and day 7, duration of hospital stay, and adverse effects (e.g., probiotic sepsis). OL OL LI { J Pediatr. These investigators included trials where neonates with hyperbilirubinemia received either clofibrate in combination with phototherapy or phototherapy alone or placebo in combination with phototherapy. 2016;109(3):203-212. Guidelines for Perinatal Care. RM Kliegman, BF Stanton, JW St. Geme, et al., eds. They used a fixed-effect method in combining the effects of studies that were sufficiently similar; and then used the GRADE approach to assess the quality of the evidence. These usually heal and resolve on their own. Malpresentations are almost always noted on the inpatient record. Cochrane Database Syst Rev. During an initial newborn evaluation, watchful waiting conditions are findings that usually resolve without medical intervention in a few weeks to a few years. 2014;165(1):42-45. list-style-type: upper-alpha; Wennberg RP. None of the studies reported on bilirubin encephalopathy rates, neonatal mortality rates, or the levels of parental or staff satisfactions with the interventions. J Pediatr (Rio J). Exchange transfusion involves taking small aliquots of blood from the infant and replacing them with donor red cells until the infants blood volume has been replaced twice to remove bilirubin and antibodies that may be causing hemolysis. 1992;89:823-824. The dose of zinc varied from 5 to 20mg/day and duration from 5 to 7 days. Treatment of jaundice in low birthweight infants. Moreover, they stated that routine use of probiotics to prevent or treat neonatal jaundice cannot be recommended; large well-designed trials are needed to confirm these findings. Treating providers are solely responsible for medical advice and treatment of members. Do not use S42.0- Fracture of clavicle for the initial encounter or subsequent professional encounters. Waltham, MA: UpToDate;reviewed January 2015; January 2017. Prediction of hyperbilirubinemia in near-term and term infants. 2005;25(5):325-330. The meta-analyses of 2 studies demonstrated a significant reduction in the length of hospital stay (MD -10.57 days, 95 % CI: -17.81 to -3.33; 2 studies, 78 infants; I = 0 %, p = 0.004; low-quality evidence). If a nurse visit is provided (e.g., weight screen only), code 99211 may be reported. The genotype of Gilbert syndrome, the UGT1A1*28 allele, causes markedly reduced activity of this enzyme, but its association with neonatal hyperbilirubinemia is uncertain and its relationship with extreme hyperbilirubinemia has not been studied. They included English-language publications evaluating the effects of screening for bilirubin encephalopathy using early TSB, TcB measurements, or risk scores. When no additional resources are used, this is not coded on the inpatient record, and is part of the pediatricians well-baby check. Toward understanding kernicterus: A challenge to improve the management of jaundiced newborns. 2016;36(10):858-861. Bilirubin recommendations present problems: New guidelines simplistic and untested. In general, serum bilirubin levels . J Perinatol. Newborn jaundice happens when the newborns liver and sunshine on the newborns skin dont remove the fetal blood components in an efficient manner. No statistical difference in the prevalence of UGTA1A1 gene variants was found between cases and controls (p = 1). Aetna's policy on treatment of hyperbilirubinemia in infants is adapted from guidelines from the American Academy of Pediatrics. #closethis { Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia. Diagnosis code Z00.121 (encounter for routine child health examination with abnormal findings) and the appropriate problem diagnosis would be used. 1992;89:821-822. It not only decreased the total serum bilirubin level after 3 days [MD: -18.05, 95 % CI: -25.51 to -10.58), p < 0.00001], 5 days [MD: -23.49, 95 % CI: -32.80 to -14.18), p < 0.00001], 7 days [MD: -33.01, 95 % CI: -37.31 to -28.70), p < 0.00001] treatment, but also decreased time of jaundice fading [MD: -1.91, 95 % CI: -2.06 to -1.75), p < 0.00001], as well as the duration of phototherapy [MD: -0.64, 95 % CI: -0.84 to -0.44), p < 0.00001] and hospitalization [MD: -2.68, 95 % CI: -3.18 to -2.17), p < 0.00001], when compared with the control group. Family physicians who perform newborn circumcision should separately report this service. A total of 25 infants had been randomized into the DXM group; 29 into the placebo group. Petersen and colleagues (2014) stated that extreme hyperbilirubinemia (plasma bilirubin greater than or equal to 24.5 mg/dL) is an important risk factor for severe bilirubin encephalopathy. Valaes T. Problems with prediction of neonatal hyperbilirubinemia. Some watchful waiting issues require continued outpatient evaluation until resolution. @media print { Do I Use 25 or 59 for Same-day Assessment and E/M? cursor: pointer; Mean STB levels, mg/dL, at 72 12 hours were comparable in both the groups (n = 286; mean difference (MD) -0.20; 95 % CI: -1.03 to 0.63). The initial day of critical care for the evaluation and management of a critically ill neonate, 28-days of age or less, is reported with code 99468. 2010;(1):CD001146. The authors found a moderate correlation between TcB and TSB during phototherapy with a marginal improvement in the post-phototherapy phase. Mehrad-Majd H, Haerian MS, Akhtari J, et al. Behrman RE, ed. These are not additional resources. Blood testing done as a diagnostic test, however, meets the requirements for coding the jaundice. 66920 Removal of lens material; intracapsular. The UGT1A1*28 allele was assessed in a case-control study of 231 white infants who had extreme hyperbilirubinemia in Denmark from 2000 to 2007 and 432 white controls. If the nurse visit results in a visit with the physician, only the physician services would be reported. Maisels MJ, Kring E. Length of stay, jaundice, and hospital readmission. Neonatology. Immaturity is not congenital absence, agenesis, stenosis, stricture, or malformation. Accessed July 16, 2002. The nurses role in caring for newborns and their caregivers. The authors concluded that this meta-analysis showed that probiotics supplementation therapy was an effective and safe treatment for pathological neonatal jaundice. Murki S, Dutta S, Narang A, et al. [Phototherapy of newborn infants] The effect of light treatment on neonates with jaundice was discovered in 1958. color: red Clin Pediatr (Phila). Mothers typically are counseled on newborn jaundice signs and when to bring the newborn in. For instance, abnormal findings on screenings for example, newborn hearing screening or lab screenings are not coded in the inpatient record, unless: Here are several watchful waiting findings to consider. Polymerase chain reaction analysis on blood spot was performed to determine the frequency of UGTA1A1 promoter polymorphisms in cases and controls. 2019;55(9):1077-1083. This indicated that cure may have been achieved in a minority of patients. These investigators evaluated the effects of antenatal phenobarbital in red cell isoimmunized pregnancies in reducing the incidence of phototherapy and exchange transfusion for the neonate. Newman TB, Maisels MJ. .strikeThrough { Santa Barbara, CA: Elsevier Saunders; 2011. 5 star restaurants st louis. More commonly seen in the documentation are: Without a diagnosis, abnormal results of routine screenings should not be coded unless the pediatrician states the abnormal results have implications for future healthcare. list-style-type: lower-alpha; Gartner LM, Gartner LM,. 1990;4(6):304-308. Randomized, controlled trial of early intravenous nutrition for prevention of neonatal jaundice in term and near-term neonates. 2011;128(4):e1046-e1052. li.bullet { Phototherapy to prevent severe neonatal hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Initial hospital or birthing center care, per day, for E/M of normal newborn infant, Initial care per day, for E/M of normal newborn infant seen in other than hospital or birthing center, Initial hospital or birthing center care, per day, for E/M of normal newborn infant admitted and discharged on the same date, Circumsion, using clamp or other device with regional dorsal penile or ring block, Circumsion, as above, without dorsal penile or ring block, Circumsion, surgical excision, other than clamp, device, or dorsal slit, neonate (28 days of age or less), Circumsion, surgical excision, other than clamp, device, or dorsal slit, neonate, old then 28 days of age. Paediatrics Child Health. After the newborn begins to breath on his own, the fetal blood is destroyed and replaced with blood that works with lungs. Infants had been treated with DXM (0.25 mg/kg twice-daily at postnatal day 1 and 2) or with placebo (normal saline). Because it is a screening (not diagnostic), the test does not meet the definition of a diagnostic procedure or therapeutic treatment for a clinically significant condition. A recent retrospective case-controlled study showed reduction in the need for exchange transfusion for the neonates from isoimmunized pregnancies. Watchful waiting conditions usually are not coded by hospital inpatient coders because the conditions do not use significant hospital resources and do not affect newborn hospitalization. Usually, hip clicks involve watchful waiting, with the tendons and muscles continuing to develop until the click is no longer felt. UpToDate[online serial]. Other methods, such as enteral feeding supplementation with prebiotics, may have an effective use in the management of hyperbilirubinemia in neonates. Our providers amend their office note to indicate the patient was admitted due to results then charge an Initial Outpatient Care code (99218-99220) for the day of admission and then 99217 for discharge. Clofibrate in combination with phototherapy for unconjugated neonatal hyperbilirubinaemia. All the studies used zinc sulfate, only 1 study used zinc gluconate. Johnson LH. Data were statistically extracted and evaluated using RevMan 5.3 software. With the sleeve pinned to the t-shirt, the newborn has restricted arm movement, and the clavicle heals without intervention. JavaScript is disabled. Approximately one in 1,000 children have congenital developmental dysplasia of the hip, which is coded Q65.89 Other specified congenital deformities of hip. Kernicterus. Sharma and colleagues (2017) examined the role of oral zinc supplementation for reduction of neonatal hyperbilirubinemia in term and preterm infants. These investigators randomly assigned 1,974 infants with extremely low birth weight at 12 to 36 hours of age to undergo either aggressive or conservative phototherapy. Data were extracted and analyzed independently by 2 review authors (MG and HM). 2002;3(1). This review included 6 RCTs that fulfilled inclusion criteria. at the end of this policy for important regulatory and legal information. 1998;101(1 Pt 1):25-31. A total of 416 records were identified through database searching; 4 studies (3 randomized studies and 1 retrospective study) meet the final inclusion criteria. Use total bilirubin. Armanian AM, Jahanfar S, Feizi A, et al. If no feeding or other health problem has been previously noted, this visit may be the first well-child visit when provided by a physician, nurse practitioner, or physician assistant. OL LI { The authors concluded that zinc sulfate could not reduce the TSB on 3 days and 7 days, the incidence of hyperbilirubinemia and phototherapy requirement, but resulted in significantly decreased duration of phototherapy. Conseil de valuation des Technologies de la Sant du Qubec (CETS). Revision Log See Important Reminder . However, there is limited evidence regarding the effect of probiotics on bilirubin level in neonates. Available at: http://www.natus.com/information/breath_analysis/. The pediatrician notes the abnormal results have implications for future healthcare. 2008;359(18):1885-1896. There is no CPT code because these hospital screenings are usually done by hospital staff who are trained by an audiologist. Randomized controlled trials were eligible for inclusion if they enrolled neonates (term and pre-term) to whom oral zinc, in a dose of 10 to 20 mg/day, was initiated within the first 96 hours of life, for any duration until day 7, compared with no treatment or placebo. Morris BH, Oh W, Tyson JE, et al; NICHD Neonatal Research Network. Long-term follow-up studies reported an increased risk of abnormal neurological examination and cerebral palsy. Liu J, Long J, Zhang S, et al. A condition does not need to be coded on the inpatient hospital encounter to be coded on the pediatricians hospital encounter. 65. For additional language assistance: SLCO1B1 (solute carrier organic anion transporter family, member 1B1) (eg, adverse drug reaction), gene analysis, common variant(s) (eg, *5), UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1) (eg, irinotecan metabolism), gene analysis, common variants (eg, *28, *36, *37), Molecular pathology procedure, Level 1(eg, identification of single germline variant [eg, SNP] by techniques such as restriction enzyme digestion or melt curve analysis) [for assessing risk of neonatal hyperbilirubinemia], Therapeutic procedure, 1 or more areas, each 15 minutes; massage, including effleurage, petrissage and/or tapotement (stroking, compression, percussion), G6PD (glucose-6-phosphate dehydrogenase) (eg, hemolytic anemia, jaundice), gene analysis, Phototherapy (bilirubin) light with photometer, Home visit, phototherapy services (e.g., Bili-lite), including equipment rental, nursing services, blood draw, supplies, and other services, per diem, Injection, phenobarbital sodium, up to 120 mg, Neonatal jaundice due to other excessive hemolysis, Neonatal jaundice from other and unspecified causes, Maternal care for other isoimmunization [not covered for the use of antenatal phenobarbital in red cell isoimmunized pregnant women], Glucose-6-phosphate dehydrogenase (G6PD); quantitative, Glucose-6-phosphate dehydrogenase (G6PD); screen, Genetic susceptibility to other disease [G6PD deficiency], Family history of other endocrine, nutritional and metabolic diseases [G6PD deficiency], Family history of carrier of genetic disease [G6PD deficiency]. Participating providers are independent contractors in private practice and are neither employees nor agents of Aetna or its affiliates. [glucose-6-phosphate dehydrogenase (G6PD), uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1), and. Per the ICD-10-PCS Official Guidelines for Coding and Reporting, only clinically significant conditions are reported. Sharma D, Farahbakhsh N, Sharma P, Shastri S. Role of oral zinc supplementation for reduction of neonatal hyperbilirubinemia: A systematic review of current evidence. Treatment effects on the following outcomes were determined: mean change in bilirubin levels, mean duration of treatment with phototherapy, number of exchange transfusions needed, adverse effects of clofibrate, bilirubin encephalopathy and neonatal mortality. Menu penelope loyalty quotes. The authors concluded that effects of screening on the rates of bilirubin encephalopathy are unknown. An example is hemangiomas (e.g., strawberry hemangiomas), which do not impinge on vital structures and are not located in the periorbital area, lip, neck, or sacral region. There was a significantly lower duration of phototherapy in the clofibrate group compared to the control group for both preterm and term neonates with a weighted mean difference of -23.82 hours (95 % CI: -30.46 hours to -17.18 hours) and -25.40 hours (95 % CI: -28.94 hours to -21.86 hours), respectively. Aetna considers home phototherapy for physiologic jaundice in healthy infants with a gestational age of 35 weeks or more medically necessary if all of the following criteria are met: Note: If levels do not respond by stabilizing (+/- 1 mg/dL) or declining, more intensive phototherapy may be warranted. Approximately 2 ml of peripheral venous blood was taken from all subjects. Maisels MJ, McDonagh AF. Phototherapy should be instituted when the total serum bilirubin level is at or above 15 mg per dL (257 mol per L) in infants 25 to 48 hours old, 18 mg per dL (308 mol per L) in infants 49 to 72 . In a Cochrane review, these investigators examined if administration of prebiotics reduces the incidence of hyperbilirubinemia among term and pre-term infants compared with enteral supplementation of milk with distilled water/placebo or no supplementation. No significant difference in mortality during hospital stay after enteral supplementation with prebiotics was reported (typical RR 0.94, 95 % CI: 0.14 to 6.19; I = 6 %, p = 0.95; 2 studies; 78 infants; low-quality evidence). Ch. When the newborn jaundice requires additional resources, the correct diagnosis is usually found under P58 Neonatal jaundice due to other excessive hemolysis or P59 Neonatal jaundice from other and unspecified causes codes. Elk Grove Village, IL: AAP; 1997. 99462 3. This is caused by a small opening in the abdominal muscles that abdominal contents (e.g., fluid, abdominal lining) spill through. The fetal blood is designed to attract oxygen from the mothers blood. It is an option to provide conventional phototherapy in hospital or at home at TSB levels 2 - 3 mg/dL below those shown, but home phototherapy should not be used in any infant with risk factors. However, that is not always the case. Yang and colleagues (2018) noted that zinc sulfate may be a promising approach to treat neonatal jaundice. Two reviewers screened papers and extracted data from selected papers. 2019;32(10):1575-1585. These researchers stated that additional large, well-designed RCTs are needed in neonates that compare effects of enteral supplementation with prebiotics on neonatal hyperbilirubinemia with supplementation of milk with any other placebo (particularly distilled water) or no supplementation. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. These investigators assessed the safety and efficacy of probiotics in reducing the need for phototherapy and its duration in NNH. Normal Newborn visit, initial service 1. Study authors were contacted for additional information. Inpatient coders do not code immature lacrimal ducts because the condition does not use additional resources. Since then, many hundred thousand infants have been treated with light. If another physician provides critical care services to the neonate on the same date, that physician must report the services with critical care service codes 99291-99292. 2017:1-10. Watchko and Lin (2010) noted that the potential for genetic variation to modulate neonatal hyperbilirubinemia risk is increasingly being recognized. } The presumed mechanism of effect is photo-excitation of bilirubin extravascularly in the skin with the formation of bilirubin isomers which can be e All searches were re-run on April 2, 2012. J Matern Fetal Neonatal Med. This reduction may be offset by an increase in mortality among infants weighing 501 to 750 g at birth. The authors concluded that phototherapy significantly interfered with the accuracy of transcutaneous bilirubinometry; TcB measurements performed 2 hours after stopping phototherapy were not reliable, even if they were performed on the unexposed body area. There was diagnostic testing or a specialty inpatient consult; or. One study reported a significant reduction in the risk of hyperbilirubinemia and rate of treatment with phototherapy associated with enteral supplementation with prebiotics (RR 0.75, 95 % CI: 0.58 to 0.97; 1 study, 50 infants; low-quality evidence). The authors concluded that in this study population, GS polymorphism alone did not appear to play a major role in severe neonatal hyperbilirubinemia in neonates without signs of hemolysis. These investigators conducted a systematic review and meta-analysis to examine the safety and efficacy of zinc sulfate on hyperbilirubinemia among neonates. 2011;100(2):170-174. Two reviewers independently assessed studies for inclusion, and discrepancies were resolved with consensus. Hamelin K, Seshia M. Home phototherapy for uncomplicated neonatal jaundice. TcB measurements were inaccurate, regardless of phototherapy technique (Bilibed, conventional phototherapy). The need for PT as well as the duration of PT were similar in both groups. If this is your first visit, be sure to check out the. Approximately 10 to 20 percent of newborns have an umbilical hernia. Otherwise healthy newborn infants with hyperbilirubinemia without signs of hemolytic disease; gestational age 33 weeks; birth weight . Chawla D, Parmar V. Phenobarbitone for prevention and treatment of unconjugated hyperbilirubinemia in preterm neonates: A systematic review and meta-analysis. Aetna considers measurement of glucose-6-phosphate dehydrogenase (G6PD) levelsmedically necessary for jaundiced infants who are receiving phototherapy, where response to phototherapy is poor, or where the infant is at an increased risk of G6PD deficiency due to family history, ethnic or geographic origin. Kernicterus in full-term infants--United States, 1994-1998. 2006;117(2):474-485. --> Coding for this service depends on the provider of the service and whether the visit is in follow-up to an already identified problem or screening for problems. Merenstein GB. Only 1 study met the criteria of inclusion in the review. American Academy of Pediatrics and American College of Obstetricians and Gynecologist. Some watchful waiting conditions include: Some conditions happen more frequently in premature newborns such as cryptorchidism and umbilical hernias. Pediatrics. The correlation coefficient improved marginally in the post-phototherapy phase (r = 0.72, 95 % CI: 0.64 to 0.78, 4 studies). For well infants 35 - 37 6/7 wk, can adjust TSB levels for intervention around the medium risk line. Ip S, Glicken S, Kulig J, et al. There was no evidence of a significant difference in duration of phototherapy between the prebiotic and control groups, which was only reported by 1 study (MD 0.10 days, 95 % CI: -2.00 to 2.20; 1 study, 50 infants; low-quality evidence). Do not confuse light treatment with ultraviolet light therapy, which is usually used for skin conditions such as psoriasis. In utero, the fetus requires larger amounts of hemoglobin for oxygenation. Effects of Gly71Arg mutation in UGT1A1 gene on neonatal hyperbilirubinemia: A systematic review and meta-analysis. The authors concluded that current studies are unable to provide reliable evidence regarding the effectiveness of prebiotics on hyperbilirubinemia. It involves the exposure of the newborn to an ultraviolet light source (bili-light) in the home for a prescribed period of time. Evaluation and management (E/M) services provided to normal newborns in the first days of life prior to hospital discharge are reported with Newborn Care Services codes. Canadian Paediatric Society, Fetus and Newborn Committee. Home phototherapy. Inpatient treatment may be medically necessary for pre-term infants who present with a TSB greater than or equal to 18 mg/dL. Discharge normal newborn day 3 _____ 2. J Paediatr Child Health. tradicne jedla na vychodnom slovensku . Cincinnati Childrens, umbilical hernia: www.cincinnatichildrens.org/health/u/umbilical-herni, Copyright 2023, AAPC Moreover, these investigators stated that infants with bilirubin levels greater than 25 mg/dL, those who are not responding to phototherapy, and those with evidence of acute bilirubin encephalopathy should be treated with exchange transfusion, with initiation based on an infants age in hours and neurotoxicity risk factors. For more information about blocked lacrimal ducts, visit: aao.org/eye-health/diseases/treatment-blocked-tear-duct. The USPSTF concluded that the evidence is insufficient to assess the balance of benefits and harms of screening for hyperbilirubinemia to prevent CBE. Reference No. Numerous skin findings may be noted, but are not coded in the inpatient record unless they are clinically significant. Casnocha Lucanova L, Matasova K, Zibolen M, Krcho P. Accuracy of transcutaneous bilirubin measurement in newborns after phototherapy. J Perinatol. } OL OL OL LI { J Adv Nurs. color: blue!important; A total of 716 neonates were included in the meta-analysis. 2010;15(3):169-175. Swelling in such a hydrocele is uniform, over time, until the fluid is absorbed by the body. The authors concluded that home-based phototherapy was more effective than hospital-based phototherapy in treatment for neonatal hyperbilirubinemia; home-based phototherapy was an effective, feasible, safe, and alternative to hospital-based phototherapy for neonatal hyperbilirubinemia. Rockville, MD: Agency for Healthcare Research and Quality (AHRQ); 2002. Seidman DS, Stevenson DK, Ergaz Z, et al. Codes 99478-99480 each are described as, "Subsequent intensive care, per day, for the evaluation and management of the recovering low or very low birth weight infant" with the code selected based. Thayyil S, Milligan DW. PubMed, Embase, Web of science, EBSCO, Cochrane library databases, Ovid, BMJ database, and CINAHL were systematically searched; RCTs evaluating the effect of zinc sulfate versus placebo on the prevention of jaundice in neonates were included. Put a thin layer of clothing, such a T- shirt, on your child's chest. It has been debated if there is an upper limit on the efficiency of phototherapy. These researchers identified studies through Medline searches, perusing reference lists and by consulting with United States Preventive Services Task Force(USPSTF) lead experts. Home Phototherapy Newborn/neonate - Age ranges from birth to 28 days Anomaly - Developmental deformity Congenital - Condition present at birth, however, may not manifest until later in life 5 Neonatal Coding Guidelines Newborn/perinatal conditions are never reported on the mother's record, and likewise, pregnancy PubMed, Scopus, Embase, Cochrane library, CBM, CNKI, and Wanfang Data were searched to collect the comparative study of home-based phototherapy versus hospital-based phototherapy for the treatment of neonatal hyperbilirubinemia. A total of 447 Chinese neonates with hyperbilirubinemia were selected as the study group and 544 healthy subjects were recruited as the control group matched by baseline sex, age, feeding pattern and delivery mode. Description This policy details medical necessity criteria for home phototherapy for the treatment of neonatal . J Pediatr Health Care. solute carrier organic anion transporter polypeptide 1B1 (SLCO1B1)] may interact with each other and/or environmental contributors to produce significant hyperbilirubinemia. 2018;31(10):1311-1317. Randomized and quasi-randomized controlled trials of pregnant women established to have red cell isoimmunization in the current pregnancy during their antenatal testing and given phenobarbital alone or in combination with other drugs before birth were selected for review.